Abstract
The female genital tract is colonised by bacteria known as the vaginal microbiota. An optimal microbiota is associated with favourable sexual and reproductive health outcomes, including being at a lower risk of HIV acquisition. Lactic acid is the main metabolic product of these optimal bacteria and here we show it helps maintaining a non-inflamed state and supports the barrier function of the vagina, which protects against HIV infection. In contrast, we found factors produced by non-optimal bacteria increased inflammation in cells from the vagina, suggesting they may contribute to increased risk of HIV acquisition in women with non-optimal vaginal microbiota.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
