Abstract
Since the recognition of microorganisms as the etiological cause of disease, scientists have studied the intimate interaction between pathogen and host in hopes of developing effective vaccines, diagnostics, and therapeutics. In turn, these studies have greatly enriched our understanding of both the microbial world and our own immune system. Early on, it became apparent that successful infection, replication and dissemination of many of the most virulent pathogens was directly tied to usurpation of host pathways that regulate and temper the immune response or that directly suppress inflammation and antigen presentation in total. Here we will discuss the modulation of host immune responses, with a special emphasis on dendritic cells and in vivo models by the highly virulent pathogens, Ebola and Marburg viruses (EBOV and MARV, respectively) and the Gram negative bacterium, Francisella tularensis.
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