Modulation of drug release mechanism by Higuchi model: Estimation of percent deviation

Abstract

The objective of this study was to develop Nicorandil floating tablets by melt granulation technique using combination of almond gum as swellable plus retarding polymer and cetosteryl alcohol as waxy plus retarding polymer. The drug release mechanism is analysed by both Higuchi model and Hixson-Crowell model based on their higher square of correlation coefficient (R2). The best formulation of MCS4 is selected based on the identical drug release profile with theoretical release data calculated from Robinson Erickson equation which follows Higuchi model for drug release from tablet core. Further, the drug release of best formulation which follow Higuchi model is checked for its deviation from an ideal Higuchi release profile. The release profiles of the best formulation is greatly deviate the ideal Higuchi release profile. In order to minimise the deviation, twotiered method is used and confirm the drug release at two phases as Hixson-Crowell model for first phase and Higuchi model for second phase.