Abstract
Poxviruses are large eukaryotic DNA viruses that have evolved a variety of strategies to evade the host immune responses to virus infection. Myxoma virus is of particular interest because it is a rabbit-specific poxvirus that induces a defined systemic virus disease, myxomatosis, in the infected European rabbit. A variety of virus-encoded proteins that are important for subverting cellular immunity and inflammation have been identified, and many of these operate by modulating or subverting cellular cytokine networks. Studies on viral proteins which mediate these immune alterations reveal a multiplicity of strategies by which poxviruses evade clearance from immunocompetent hosts and also identify a new class of immunomodulatory proteins with which to investigate the effector functions of the immune system.
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