Abstract
Addition of LiCl (1–25 m M) to serum-free cultures of MHA hamster thymocytes, lymph node cells, or splenocytes stimulated with concanavalin A had a biphasic effect on [ 3H]thymidine incorporation. These concentrations of LiCl enhanced stimulation of [ 3H]thymidine incorporation by suboptimal levels of concanavalin A but inhibited stimulation of optimal and supraoptimal concentrations of concanavalin A. This effect was specific for Li + since it was not observed when similar concentrations of Na +, K +, or Mg 2+ were added to cultures stimulated by concanavalin A. The inhibitory effect of LiCl on concanavalin A stimulation was not reversed by addition of Na +, Ca 2+, Mg 2+, or Ca 2+ + Mg 2+ to the cultures. Significant reversal of LiCl inhibition of stimulation was observed when KCl was added to the cultures. However none of the ions tested blocked the Li-induced enhancement of [ 3H]thymidine incorporation in the presence of suboptimal concentrations of concanavalin A.
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