Abstract
Can photothermal gold nanoparticle mediated laser manipulation be applied to induce cardiac contraction? Based on our previous work, we present a novel concept of cell stimulation. A 532 nm picosecond laser was employed to heat gold nanoparticles on cardiomyocytes. This leads to calcium oscillations in the HL-1 cardiomyocyte cell line. As calcium is connected to the contractility, we aimed to alter the contraction rate of native and stem cell derived cardiomyocytes. A contraction rate increase was particularly observed in calcium containing buffer with neonatal rat cardiomyocytes. Consequently, the study provides conceptual ideas for a light based, nanoparticle mediated stimulation system.
Highlights
Various applications in the biomedical research field have started to combine gold nanoparticles with laser irradiation
Can photothermal gold nanoparticle mediated laser manipulation be applied to induce cardiac contraction? Based on our previous work, we present a novel concept of cell stimulation
In this study, we investigated the feasibility of gold nanoparticle mediated laser stimulation in the cardiac myocyte cell line HL-1, rat neonatal cardiomyocytes, and human embryonic stem cell (hESC-)derived cardiomyocytes
Summary
Various applications in the biomedical research field have started to combine gold nanoparticles with laser irradiation These include techniques for the sensitive detection of molecules [1,2] and methods for cell treatment or manipulation, such as photothermal therapy [1,3,4] or cell transfection [5,6,7,8]. It has to be determined if the same principle would be applicable to a direct modification of molecule or cell function. Four important concepts for induction of cardiac activity using optical methods were demonstrated [14,15,16,17]
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