Abstract
1. 1.The goal was to verify if central or peripheral sulphated cholecystokinin octapeptide (CCK8) injections can modulate apomorphine (APO)-induced stereotyped behavior. Experiments were designed to determine the involvement of cholecystokinin receptor subtypes as well. 2. 2. Animals which received CCK8 (0.0725, 0.145 and 14.5 nmol, icv) showed a significant ( p < 0.05) decrease in APO (0.6 mg/kg, sc)-induced stereotyped behavior. 3. 3. No other statistically significant difference was observed among groups. Since ip CCK8 (1.16 or 2.32 nmol/kg) injections did not interfere with APO-induced stereotypy, the results suggest that the CCK8 modulatory effects have a central action. 4. 4. The results also suggest that the effects of icv CCK8 were not due to the stimulation of CCK B receptors alone since central CCK4 (14.5 or 29.0 nmol) injections did not interfere with the expression of stereotypy.
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