Abstract
Background HIV-1 infection generates numerous abnormalities in the B cell population. The majority of these defects are reverted by antiretroviral therapy. Our aim was to evaluate the effects of re-exposure to HIV antigens on the frequency and functionality of antibody secreting cells (ASC) in patients undergoing structured treatment interruptions (STI). As re-exposure to viral antigens may also boost the production of (neutralizing) antibodies, we also assessed the neutralizing activities during STI cycles. Methods Retrospective study of 10 patients undergoing 3 cycles of STI with 2 weeks on and 4 weeks off HAART. ASC frequencies were determined by flow cytometry in samples obtained at the beginning and the end of STI. Neutralization capacity, total IgG concentration and anti-gp120-IgG titres were evaluated.
Highlights
HIV-1 infection generates numerous abnormalities in the B cell population
Our aim was to evaluate the effects of re-exposure to HIV antigens on the frequency and functionality of antibody secreting cells (ASC) in patients undergoing structured treatment interruptions (STI)
In one patient the neutralizing activity remained constant while the second patient showed elevated neutralizing Ab after first STI and once treatment was reinitiated after the 2nd STI
Summary
HIV-1 infection generates numerous abnormalities in the B cell population. The majority of these defects are reverted by antiretroviral therapy. Our aim was to evaluate the effects of re-exposure to HIV antigens on the frequency and functionality of antibody secreting cells (ASC) in patients undergoing structured treatment interruptions (STI). As re-exposure to viral antigens may boost the production of (neutralizing) antibodies, we assessed the neutralizing activities during STI cycles
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
