Modulation of allergen-specific antibody responses by T-cell-based peptide vaccine(s). Principles and potential.

Abstract

Extensive studies of immunopathology of asthma have revealed the predominant role of T-cells in driving the inflammatory responses associated with bronchial asthma and the role of allergen-induced IgE responses in exacerbating the asthmatic responses. With recent advances in molecular immunoallergology, in general, and the role of T-cells in asthma in particular, it has become apparent that therapy invooving T-cell-based vaccines may provide a rational immunologic approach(es) for the treatment of specific allergen induced asthma. Three main approaches appear to have potential: 1. Immunotherapy with allergen in combination with appropriate cytokines; 2. Vaccinations with T-cell epitopic peptides; and 3. Vaccinations with T-cell receptor peptides.