Abstract
Antidepressant drugs are generally thought to act by changing aminergic neurotransmission. Thus, according to the indoleamine hypothesis1, antidepressant drugs increase the amount of serotonin (5-HT) available at the receptor level by inhibition either of 5-HT uptake or of its degradative enzyme (monoamine oxidase)2. Various experimental observations have, however, suggested that the effects of antidepressant drugs may be located at the postsynaptic receptor level3–7. We report here that antidepressant drugs alter the structural conformation of the postsynaptic serotoninergic receptor in synaptosomal membranes isolated from rat and horse brains in such a way as to inactivate them.
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