Abstract
The spike peak and after-hyperpolarization of the action potential of bullfrog sympathetic ganglion cells were depressed during the late slow excitatory postsynaptic potential (EPSP). These changes in the action potential were mimicked by luteinizing hormone-releasing hormone (LH-RH), a neurotransmitter candidate for the late show EPSP. LH-RH (5 μM) suppressed the voltage-dependent K + currents, both the delayed rectifier K + current (I K1) and the M current (I K2). It is suggested that the depression of the after-hyperpolarization of the action potential during the late slow EPSP may be due to suppression of I K1 and I K2.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have