Abstract
Intraventricular administration of ACTH 1–24 into the rat induced excessive grooming behavior. This response could be blocked by local administration of neuroleptics into either the nucleus accumbens or the neostriatum. Local administration of [Des-Tyr 1]-γ-endorphin (LPH 62–77) but not α-endorphin (LPH 61–76) in either the nucleus accumbens or the neostriatum mimicked the effect of the neuroleptics. A second intraventricular injection of ACTH 1–24 4 h after the first did not cause excessive grooming suggesting the development of acute tolerance. Both haloperidol and DTγE reduced the development of acute tolerance to ACTH-induced grooming. It is suggested that DTγE modulates the dopaminergic activity underlying the display of ACTH-induced excessive grooming.
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