Modulation of acoustic radiation forces on three-layered nucleate cells in a focused Gaussian beam

Abstract

The acoustic cell manipulation is of great interest to many applications. A three-layered micro-shell (TLS) model is proposed to simulate the three-layered nucleate cell. Acoustic radiation forces (ARFs) of a focused Gaussian beam on the TLS are studied theoretically. The ARF may change from positive to negative if the TLS moves across the centre of the beam waist. Besides, the smaller the beam waist radius is, the stronger the ARF is. It is found that the geometry parameters of the TLS have great influence on the ARF. The positive ARF increases with the inner core radius while the negative ARF grows strong at first and then descends. With increasing thickness of the outer shell, the positive ARF is enhanced while the negative ARF is depressed and might even turn into positive. We further found that sound velocities in the TLS also affect the ARF significantly.