Abstract
The present study was designed to evaluate the therapeutic effectiveness and mechanism of intermittent hypoxia on respiratory function at distinct injured stages following mid‐cervical spinal cord contusion. In the first study, adult male rats were received laminectomy or unilateral contusion at 3rd–4th cervical spinal cord at 9 weeks of age. The ventilatory behavior in response to mild acute intermittent hypoxia [10 episodes of 5 min of hypoxia (10 % O2, 4 % CO2, 86 % N2) with 5 min of normoxia intervals] was measured by the whole body plethysmography at the acute (~3 day), subchronic (~2 week) and chronic (~8 week) injured stage. The minute ventilation of contused animals could be significantly enhanced following intermittent hypoxia due to augmentation of the tidal volume at all time points post‐injury. However, this intermittent hypoxia‐induced ventilatory long‐term facilitation was only observed in uninjured animals at the acute stage. In the second study, the effect of intermittent hypoxia on respiration was examined in contused animals after blockade of serotonin receptors or adenosine 2A receptors. The result demonstrated that intermittent hypoxia‐induced enhancement of minute ventilation was attenuated by serotonin receptor antagonist (methysergide) but rather enhanced by adenosine 2A receptor antagonist (KW6002) at the subchronic and chronic injured stages. These results suggested that intermittent hypoxia can induce respiratory recovery from the acute to chronic injures stages, and the therapeutic effect were dampened by inhibition of serotonin receptors but could be amplified by blockade of adenosine 2A receptors.Support or Funding InformationMinistry of Science and Technology (105‐2628‐B‐110‐002‐MY3), Higher Education Sprout Project (07C030111) and NSYSU‐KMU Joint Research Project (107‐I001)This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
