Abstract
Extracts of ginkgo biloba have been broadly prescribed toward advance symptoms of cognitive dysfunction ranging in severity from mild memory loss to dementia also; in delaying the development of dementia; ginkgo biloba has been encouraged commercially as a smart medicine to augment the brain function of healthy people. Piracetam is a no tropic remedy correlated to inhibitory γ-aminobutyric acid (GABA) neurotransmitter. Piracetam may be the initial agent acting on cognitive function without sedation. Thirty subjects (30 males) arbitrarily choose as of medical college students. The contributors were allowable to perform mutually on the psychomotor performance device tester and the computerized n-back test (working memory task) to obtain knowledge from those tests sooner than the commencing of the examination. All psychometric response time and working memory test parameters calculated previous to the experimental research, so the identical volunteers considered as control and through four days of receiving the ginkgo biloba 60mg/day (trunature GSL),piracetam 800 mg/day (neutrophil) or both drugs so the enrolled participants divided into three groups .Group A take ginkgo biloba, group B take piracetam and group C take piracetam and ginkgo biloba. Piracetam significantly improve cognitive and working memory at all levels P<0.05 while it showed insignificant effects on psychometric reaction time parameters except it ameliorate the total reaction time (TRT) P <0.05. The differential effects of ginkgo biloba showed significant effects on psychometric reaction time and cognitive central Integrity P<0.05 and insignificant effects on working memory accuracy except at level Ð-Back where it produced significant effects P<0.05. Combined effects of ginko biloba and piracetam on psychomotor performances, cognitive function and working memory produced significant effects P <0.05. Conclusion: Combined effects of piracetam and ginkgo biloba produced more significant effects than either ginkgo biloba or piracetam alone on cognitive function and working memory.
Highlights
Extracts of ginkgo biloba have been broadly prescribed toward advance symptoms of cognitive dysfunction ranging in severity from mild memory loss to dementia ; in delaying the development of dementia; ginkgo biloba has been encouraged commercially as a smart medicine to augment the brain function of healthy people
; the duration of time wanted for red color recognition be described as (RRT) recognition reaction time which corresponded toward the instant starting stimulus beginning to the commencement of motor action,while the duration of time starting movement act to the end of response named (MRT) movement reaction time
All psychometric response time and working memory test parameters calculated previous to the experimental research,so the identical volunteers considered as control and through four days of receiving the ginkgo biloba 60mg/day,piracetam 800mg/day or both drugs so the enrolled participants divided into three groups .Group A take ginkgo biloba, group B take piracetam and group C take piracetam and ginkgo biloba
Summary
Extracts of ginkgo biloba have been broadly prescribed toward advance symptoms of cognitive dysfunction ranging in severity from mild memory loss to dementia ; in delaying the development of dementia; ginkgo biloba has been encouraged commercially as a smart medicine to augment the brain function of healthy people. ; it inhibits nitric oxide production during ischemia[6,7], ginkgolides present in ginkgo biloba have been classified as nootropic agent ; the haemorheological property of ginkgo and the assumed effects on neurotransmitters are reasonable mechanisms by which the ginkgo might not merely apply a protective effect against dementia and improve standard cognition in normal healthy subjects[8,9]. Frequent administration of piracetam and ginkgo biloba may result in so called behavioral sensitization, which plays an important role in cognition so; an increased reaction to the same dose of drug after preceding long-term alternating administration of this drug. The aims in the attending study were to approximate the advancement outcomes of ginkgo and or piracetam on cognitive, psychomotor performances and working memory functions in normal young male's healthy persons and to confirming the modulation effects
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