Abstract
The utilization of dendritic nanocarriers for enhanced skin delivery of active agents has been gaining growing popularity. However, the capability of dendrimers for skin delivery management has been under debate. As passive permeation of molecules is inversely related to the molecular weights, the purpose of this work was to investigate the extent to which the low-generation poly(amidoamine) (PAMAM) dendrimers enhance the skin penetration of a model active agent, salicylic acid. The aqueous solutions of amine-terminated (G2 and G3) PAMAM (1-10 mM) were employed to pre-treat the full-thickness pig skin, which was followed by the application of saturated aqueous drug solution. The results showed that G3 PAMAM did not exhibit an improvement of drug steady-state flux. In contrast, the skin pre-treatment by G2 PAMAM demonstrated a significant increase of drug flux up to ca. 2 folds in a dendrimer concentration-dependent manner. This study suggested the limited ability of low-generation PAMAM in modulating drug delivery to the skin.
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