Abstract
Membrane-covered Express2TM Monorail® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs.
Highlights
Restenosis is an inflammatory response that may involve thrombus formation causing the renarrowing of a coronary artery
To simulate the friction generated during the application of a stent via a balloon catheter inside a blood vessel and to assess the membrane integrity during inflation of the CH-polyethylene oxide (PEO)/hyaluronic acid (HA) covered stent inside the 2mm tube, the procedure was monitored with a microscope through a quartz cuvette which was attached to the tubing
We have reported a membrane-covered stent from CH-PEO blends with attractive mechanical properties and enhanced drug loading and release capacity
Summary
Restenosis is an inflammatory response that may involve thrombus formation causing the renarrowing of a coronary artery. HA has been used to cover stents via cross-linking with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) leading to a reduced inflammatory response compared to un-coated stainless steel stents in pig coronary arteries [23] It significantly reduced platelet deposition by 55% after 2 hours of blood exposure in exteriorized arteriovenous shunts in baboons [21]. Many stuudies have reported thhe release behaviour of hydrophhobic drugss from various polymeer s systems; how wever no coomparative studies are available showing s thee effect of thhe drug load ding strateggy. In this woork, our aim o release behaviour on b m modulation. Druug release sttudies for thhe thhree system ms were caarried out in i an ethannol/water solution maaintaining sink conditiions and thhe released Pacc was quanttified usingg HPLC andd UV spectrrometry andd data furthher fitted in n the Higuchhi m model [26]
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