Abstract
As part of a substantial effort to curtail the adverse health effects posed by aflatoxin B1, studies have been conducted to elucidate the possible mechanism for the anticarcinogenic action of Semecarpus anacardium nut extract against aflatoxin B1-induced hepatocellular carcinoma. Rats are monitored for levels of urinary, serum and liver biomarkers, namely, unmetabolised aflatoxin B1, and its metabolites aflatoxin M1, and aflatoxin Q1, over the course of 2 weeks with nut extract therapy following a single-exposure to aflatoxin B1. Due to the administration of nut extract, the excretion of unmetabolised aflatoxin B1was increased in day 1 urine when compared with rats without drug treatment. In serum and liver which were collected on day 16 and the rest of periodical urine samples showed aflatoxin B1and its metabolites in undetectable levels. The nut extract administration induced cytochrome P450, glutathione, and glutathione- S -transferase levels in liver homogenates of aflatoxin B1-treated rats. These data seem to indicate that anticarcinogenic action by Semecarpus anacardium nut extract is possibly via suppression of aflatoxin B1activation and through interaction with microsomal-activating components. Previous evidence from this laboratory about the potency of Semecarpus anacardium nut extract against aflatoxin B1-induced hepatocellular carcinoma together with the present results suggest that extremely effective therapeutic protection can be achieved by this drug against aflatoxin B1-mediated ill effects.2000 Academic Press@p$hr
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
