Abstract
Meeting abstracts The ability of tumor-reactive CD8+ T cells to eradicate tumors following adoptive transfer of autologous tumor-infiltrating lymphocytes correlates with their capacity to proliferate and persist for long periods of time. These qualities are found predominantly in naive and less
Highlights
Modulating immunometabolism of tumor specific CD8 T cells to enhance T cell based therapy for cancer
The ability of tumor-reactive CD8+ T cells to eradicate tumors following adoptive transfer of autologous tumorinfiltrating lymphocytes correlates with their capacity to proliferate and persist for long periods of time
T cells divert their bioenergetic metabolism from oxidative phosphorylation to aerobic glycolysis
Summary
Modulating immunometabolism of tumor specific CD8 T cells to enhance T cell based therapy for cancer. Sukumar et al Journal for ImmunoTherapy of Cancer 2014, 2(Suppl 3):O2 http://www.immunotherapyofcancer.org/content/2/S3/O2 From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA.
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