Modulating effects ofAllium sativum(garlic) extract in monosodium glutamate induced injuries in rats

Abstract

This study investigates the toxicity effect of monosodium glutamate (MSG) on some tissues of rats and the effect of its combined administration with garlic. Thirty five rats randomized to 5 groups were used. Group B (7 rats) was placed on MSG (200mg/Kg/day). Group C (21 rats) was simultaneously administered with MSG and garlic (260mg/Kg/day). After 28 days of continuous treatment, 7 rats were sacrificed in each group. The rest rats in group B were redistributed into groups D and E. Group D was treated with garlic. Blood was withdrawn after the next 28 days treatment period. The liver, kidney and uterus were also removed. The results indicated that MSG increased plasma cholesterol, triglyceride, LDL, atherogenic and coronary risk index, fasting blood glucose and total protein but decreased plasma HDL. None of these parameters were altered when MSG and garlic were coadministered and when garlic was administered after MSG withdrawal. Although none of the rat's uterus showed any morphological change, significant increase in the body weight and relative organ weight were observed with MSG administration. The study suggested that MSG intake may elicit cardiovascular disorder and may also pose serious toxicological threat to cardiovascular tissues and the garlic has protective and ameliorative effect.