Abstract
The family of nucleic acid (NA) strand separation enzymes known as helicases are found in all organisms and participate in a wide variety of cellular processes. The central reaction catalyzed is always the same: hydrolysis of a nucleoside triphosphate (NTP; usually ATP) is coupled to the separation of an NA duplex, be it DNA-DNA, DNA-RNA, or RNA-RNA. This central process is required in almost every aspect of NA metabolism in the cell, including chromosomal and plasmid replication, transcription, translation, RNA processing, and DNA recombination and repair (30, 46). This widespread usage may be seen by examining the cellular complement of helicases; for example, at least 12 putative DNA helicases have been identified in the genome of Escherichia coli, while it has been estimated that more than 2% of the Saccharomyces cerevisiae genome encodes helicase-related proteins (48).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
