Abstract
A method for the modular one-pot synthesis of tetra-substituted furans utilizing alkynes, Weinreb amides, and non-enolizable aldehydes has been developed. Under this titanium promoted method, furans were prepared in moderate yields with high levels of regioselectivity. The system showed good chemoselectivity tolerating aromatic and aliphatic bromides, chlorides, and fluorides, heteroaromatics, alkenes, and silyl ethers.
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