Abstract
AbstractA novel palladium(0)‐catalyzed dearomatizing [2+2+1] spiroannulation of 1‐bromo‐2‐naphthols with aryl iodides and alkynes was developed for the rapid assembly of spiro[indene‐1,1′‐naphthalen]‐2′‐ones. This three‐component cascade reaction was realized through consecutive Catellani‐type C−H activation, unsymmetrical biaryl coupling, alkyne migratory insertion, and arene dearomatization. The potential utility of our method is illustrated by the one‐step construction of the polycyclic skeletons of dalesconols A and B from alkyne‐tethered aryl iodides and 1‐bromo‐2‐naphthol.
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