Abstract
ObjectiveTo determine the genetic susceptibility of plasminogen activator inhibitor-1 (PAI-1) and gly-coprotein (GP) IIb/IIIa platelet receptor genes in the pathogenesis of the coagulation system activation in gestational diabetes (GD). Material and methodsSamples were taken from 151 pregnant women, n = 74 gestational diabetes and n = 77 control group. The genetic polymorphisms for the GP IIb/IIIa and PAI-1 genes were determined and coagulation system parameters (tissue factor, S protein, C protein, antithrombin III, factor II, fibrinogen, TPTA, thromboplastin and D-dimers) were measured. Statistical significance was if a computed two-tailed probability was less than 5% (p = 0.05). Results4G allele was associated with a greater risk factor for developing complications in women with GD (32% vs 53.1% for the presence and absence of complications, respectively). In the GD group the fibrinogen values were significantly different for the A1A1 genotype and the A1A1/5G5G haplotype (p < 0.05). ConclusionsThe association of some allelic-genotype combinations of the markers analyzed in the GD group seems to have a genetic participation in the variability of some coagulation parameters in this population.
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