Abstract
This paper reports a newly fabricated nanophyto-modified wound dressing with microbicidal and anti-adherence properties. Nanofluid-based magnetite doped with eugenol or limonene was used to fabricate modified wound dressings. Nanostructure coated materials were characterized by TEM, XRD, and FT-IR. For the quantitative measurement of biofilm-embedded microbial cells, a culture-based method for viable cell count was used. The optimized textile dressing samples proved to be more resistant to staphylococcal and pseudomonal colonization and biofilm formation compared to the uncoated controls. The functionalized surfaces for wound dressing seems to be a very useful tool for the prevention of wound microbial contamination on viable tissues.
Highlights
Humans are natural hosts for many bacterial species that colonize the skin and mucosa as normal microbiota
We have demonstrated by scanning electron microscopy the ability of Fe3O4@C18 to prevent the fungal adherence of Candida albicans on optimized textile dressing samples coated with functionalized magnetite nanoparticles, as compared to uncoated materials [36]
Limonene and eugenol, the major compounds of essential oils extracted from Anethum graveolens (56.53%) and Eugenia caryophyllata (92.45%) proved, to exhibit very good antimicrobial properties [28,44]
Summary
Humans are natural hosts for many bacterial species that colonize the skin and mucosa as normal microbiota. One of the most efficient strategies is to interfere with bacterial adherence, the first step in the biofilm formation, by direct blockage of surface receptors [8] or using a non-specific strategy, usually involving compounds with antiadherence properties [9,10,11]. Another efficient strategy seems to be the one involving the manipulation of communication processes between bacteria into the biofilm, using different natural or artificially synthetized compounds [12,13,14]. The use of essential oils can be limited by their high volatility and low stability [19]
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