Abstract
Objective To investigate the effect of modified poly L acid-type collagen I loaded with bone marrow mesenchymal stem cell （BMSCs） for diabetic wound of rat. Methods 36 diabetic rats were randomly divided into 3 groups： A （poly L acid-type collagen I ＋ BMSCs）, B （poly L acid-type collagen I） and C （ control）, the wound healing was observed and the cytokeratin in 5-BrdU BMSCs was detected. Re- suits The wound healing rate in 3, 5, 7, 14 d of group A were （18. 20 ± 2. 68 ） % , （30.60±5.50）%, （57. 63 ±9. 13）%, （87. 35 ±5. 83 ）% respectively and faster than group B （P 〈 0. 05） and group C （ P 〈 0. 05 ） , the newly-grown skin in group A had more blood vessel, cutaneous appendages and thicker than group B and group C, the cytokeratin were detected in the 5-BrdU BMSCs. Conclusion Modified poly L acid-type collagen I loaded with BMSCs can promote the rat diabetic wound healing. Key words: Bone marrow mesenchymal stem cells; Diabetic wound
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
