Abstract
Materials sized 1–100 nm are the nanotechnology’s field of interest. Because of the unique properties such as the ability to penetrate biological barriers and a high surface to volume ratio, nanoparticles (NPs) are a powerful tool to be used in medicine and industry. This review discusses the role of nanotechnology in bone-related issues: osteosarcoma (bone cancer), the biocompatibility of the implants and implant-related infections. In cancer therapy, NPs can be used as (I) cytotoxic agents, (II) drug delivery platforms and (III) in thermotherapy. In implant-related issues, NPs can be used as (I) antimicrobial agents and (II) adjuvants to increase the biocompatibility of implant surface. Properties of NPs depend on (I) the type of NPs, (II) their size, (III) shape, (IV) concentration, (V) incubation time, (VI) functionalization and (VII) capping agent type.
Highlights
Miniaturisation affects every aspect of human life; medicine and science are no exceptions.Nanotechnology is interested in particles within the 1–100 nm size range [1]
Rahim et al have shown that 24.3 nm gold nanoparticles (AuNPs) capped with advance glycation products can decrease cell viability and trigger apoptosis in Saos-2 cells [19]
Kovacs et al have shown that 5 nm and 35 nm citrate-AgNPs influenced the viability of two osteosarcoma cell lines U2OS and Saos-2 [23]
Summary
Miniaturisation affects every aspect of human life; medicine and science are no exceptions. We discuss the role of nanotechnology in the novel treatment of bone diseases. The human body over 206 bones, which a variety of functions: locomotion, protection of internal organs, ionhas homeostasis and blood cellsserve production [7,8,9]. We discuss theblood role ofcells nanotechnology in theUnfortunately, novelissues treatment of bone from diseases and be the cause of health-related issues. Of new neoplasm cases in adolescents), bone metastases happen often and by for reached almost. Quality life in end-stage disease reached almost $50 in decrease the United alone [11].ofAlthough primary bone [12,13]. Osteosarcoma relatively rare (7% of new neoplasm cases in adolescents), bone metastases happen often and by.
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