Abstract
A multiwall carbon nanotubes modified electrode was prepared using ferrocenedicarboxylic acid as a mediator to be used as an amperometric sensor for the simultaneous determination of 6-thioguanine and folic acid. The electrochemical behaviors of the compounds at this modified electrode were studied using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. The results indicated that the chemically modified electrode exhibited an efficient electrocatalytic activity towards the oxidation of 6-thioguanine and folic acid at pH 9.0. Using chronoamperometry, the catalytic reaction rate constant was calculated at 8.2 × 10 2 (mol L −1) −1 s −1. The catalytic peak current was linearly dependent on 6-thioguanine and folic acid concentrations in the range of 0.01–100 μmol L −1 6-thioguanine and 4.6–152 μmol L −1 folic acid. The detection limits for 6-thioguanine and folic acid were 0.0085 μmol L −1 and 1.1 μmol L −1, respectively. The RSD% for 10 replicates determination of 0.70 and 11.0 μmol L −1 of 6-thioguanine were 1.3% and 1.1%, respectively, whereas for 15.0 and 30.0 μmol L −1 folic acid, they were 0.9% and 1.1%, respectively. The modified electrode showed good sensitivity, selectivity, and stability. It was successfully applied for the determination of both 6-thioguanine and folic acid in real samples.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
