Abstract
Pulmonary focal Ground-glass Opacities (fGGOs) would frequently be identified after widely implementation of low-dose computed tomography (LDCT) screening. Because of the high false-positive rate of LDCT, antibiotics should be regarded as advocates in clinical management for detected fGGOs. Retrospectively review consecutive patients with fGGOs between August 2006 and August 2012. Then, relative Glasgow prognostic score (GPS) were constructed in three different systems, traditional GPS system (tGPS), modified GPS system 1 (m1GPS), and modified GPS system 2 (m2GPS). Moreover, propensity score matching (PSM) was employed in balancing baseline covariates. After PSM, patients were matched and included in benign and malignant groups as 1:1 ratio. All reported parameters were balanced in both groups and no statistical differences could be detected. Finally, m1GPS exhibited remarkable different distribution between benign and malignant fGGOs. In detail, m1GPS 1 was more frequently observed in benign fGGOs nodules, while m1GPS 2 in malignant fGGOs nodules. Modified inflammation-based score was identified as an independent predictor of malignancies in patients with pulmonary fGGOs. Patients with m1GPS 1 were more likely to be benign fGGOs, while victims with m1GPS 2 more likely to be malignant.
Highlights
Characteristic Age, yrs Smoking history, pack-yr Time since smoking cessation, yr Sex(%) Male Female Symptom Absent Present History of other lung diseases Absent Present History of lung cancer Absent Present History of other cancers Absent Present Family history of lung cancer Absent Present
Given the fact of increasing detection of lung focal Ground-glass Opacities (fGGOs) and a paucity of evidence on clinical antibiotics utilities[23], this preliminary study was designed with the aim of identifying an effective predictor of antibiotics use in treatment after lung fGGOs detection
The current preliminary study, after evaluating and comparing different inflammation-based score systems, identified m1GPS as an effective predictor of antibiotics use in treatment after lung fGGOs detection
Summary
Clinical outcomes. 128 patients with pulmonary fGGOs nodules were eligible for the final analysis. The standardized difference in means and distribution of propensity scores consistently illustrated improvement of covariate balance after PSM (Figs 1 and 2) In this group of 82 patients, the mean age was 53.5 years. The distribution of m2 GPS score was m2 GPS 0 in (33.3%) patients, m2 GPS 1 in (35.3%) patients, and m2 GPS 2 in 16 (31.4%) of benign fGGOs; and m2 GPS 0 in 20 (26.0%) patients, m2 GPS 1 in 17 (22.1%) patients, and m2 GPS 2 in 40 (51.9%) of malignant fGGOs, (Table 5). No statistical differences could be observed between benign and malignant fGGOs nodules among these 128 patients in aspects of tGPS (p = 0.553), m1GPS (p = 0.383) and m2GPS (p = 0.064) (Tables 3–5). The suitable cut-off values should be 10 mg/L for elevated CRP level and 35 g/L for hypoalbuminemia
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
