Modified Fe3O4/HAp Magnetically Nanoparticles as the Carrier for Ibuprofen: Adsorption and Release Study.

Abstract

The adsorption capacity and release attributes of magnetic Fe3O4@hydroxyapatite (Fe3O4/HAp) nanoparticles for drug molecules can be improved by modified their surfaces with logical chosen organic groups. The internal surface of nanoparticles was functionalized with (3-aminopropyl) trimethoxysilane (APTS). Comparative studies of their adsorption and release properties for various model drug molecules (such as pure hydroxyapatite, Fe3O4@hydroxyapatite and functionalized Fe3O4@hydroxyapatite) were then conducted. The characteristic of the obtained materials was performed with X-ray-diffraction (XRD), energy dispersive X-ray microanalysis (EDS), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), UV-Vis analysis, vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). Results show that functionalized magnetic Fe3O4@hydroxyapatite nanoparticles leads than a substantial decrease of the drug delivery rate in pH=6.8 after investigated drug release in intestine environment. In addition, the results demonstrate that high adsorption capacity for drug and slower drug release rate was obtained after functionalized nanoparticles than Fe3O4@hydroxyapatite and pure hydroxyapatite.