Modified D-optimal design for logistic model

Abstract

Asymptotic theory of using the Fisher information matrix may provide poor approximation to the exact variance matrix of maximum likelihood estimation in nonlinear models. This may be due to not obtaining an efficient D-optimal design. In this article, we propose a modified D-optimality criterion, using a more accurate information matrix, based on the Bhattacharyya matrix. The proposed information matrix and its properties are given for two parameters simple logistic model. It is shown that the resulted modified locally D-optimal design is more efficient than the previous one; particularly, for small sample size experiments.