Modified Complete Blood Count Indices as Predicting Markers of Preeclampsia from Gestational Hypertension: Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Platelet to Neutrophil Ratio.

Abstract

To evaluate modified complete blood count (CBC) indices as a predicting marker of preeclampsia (PE) from gestational hypertension (GH), we analyzed the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and platelet to neutrophil ratio (PNR). PNR was a newly designed index in this study based on results of PE patients having a tendency toward higher neutrophil count and lower platelet count compared to normal pregnant women in previous studies. We recruited 86 normal pregnant women, 33 patients with GH and 68 patients with PE. Subjects with any history of membrane rupture, infection, or multiple pregnancies were excluded. PNR, NLR, and PLR values including other CBC indices were statistically analyzed. NLR value of PE patients was significantly higher than GH patients (p = 0.011). PNR value was the most statistically significant index separating patients with PE and GH (p < 0.001). PLR value was lower in patients with PE compared to GH; however, statistical significance was low. NLR as well as PNR is a useful index to help predicting progression from GH to PE. Further studies are required to evaluate the full extent of utility of PNR as a predictive index in PE patients.