Abstract
A simple and convenient method is described for voltammetric determination of carbidopa (CD), based on its electrochemical oxidation at a modified multiwall carbon nanotube paste electrode. Under optimized conditions, the proposed method exhibited acceptable analytical performances in terms of linearity (over the concentration range from 0.1 to 700.0 μM), detection limit (65.0 nM), and reproducibility (RSD = 2.5%) for a solution containing CD. Also, square wave voltammetry (SWV) was used for simultaneous determination of CD, folic acid (FA), and tryptophan (TRP) at the modified electrode. To further validate its possible application, the method was used for the quantification of CD, FA, and TRP in urine samples.
Highlights
Electrochemical detection of analyte is a very elegant method in analytical chemistry [1]
We have previously shown that a carbon paste electrode spiked with FCD is constructed by the incorporation of FCD in a graphite powder-paraffin oil matrix [47]
The experimental results show that well-defined and reproducible anodic and cathodic peaks were related to ferrocene dicarboxylic acid/ferricenium dicarboxylic acid (Fc/Fc+) redox system, which show a quasireversible behavior in an aqueous medium [48]
Summary
Electrochemical detection of analyte is a very elegant method in analytical chemistry [1]. There are reports on the synthesis of multiwalled carbon nanotubes (MWCNTs) [9] and single-walled carbon nanotubes (SWCNTs) [10]. These materials have attracted enormous interest because of their unique structural, mechanical, electronic, and chemical properties. The subtle electronic properties suggest that CNTs have the capability of promoting electron transfer reactions and improving sensitivity in electrochemistry, and they are widely used as electrodes [11,12,13]. CNT modified electrodes have been proved to have excellent electroanalytical properties, such as wide potential window, low background current, low detection limits, high sensitivities, reduction of over potentials, and resistance to surface fouling. There are reports that reveal that CNT modified electrodes have shown electrocatalytic behavior with excellent performance in the study of a number of biological species [14,15,16,17,18]
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