Abstract
Compounds having quinolone and pyrimidine skeleton plays an important role in the medicinal chemistry. The objective of the present work was to modify the Biginelli reaction by using heterocylic ketones under microwave condition. We have demonstrated new synthetic route of quinolone fused 1,4-dipyrimidines by the reaction of 6-methyl-4-hyrdoxyquinolin-2(1H)-one (1), substituted aromatic aldehydes (2a-g) with phenyl urea (3). The structure of these newly synthesized compounds was characterized IR, NMR, Mass spectral and elemental analysis.
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