Abstract
Super-resolution methods allow the visualization of phenomena thus far elusive to light microscopy. While current implementations are technically approaching true molecular-scale resolution, this does not translate to imaging biological specimen, due to the unavailability of small affinity reagents. Here, we introduce SOMAmers as labeling reagents for DNA-PAINT. We demonstrate the achievable resolution and specificity by labeling and imaging of transmembrane as well as intracellular targets in fixed and live cell-specimen.
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