Abstract
other than copper. Attachment of a carboxyl functionality to the Cu(ATSM) core permits orthogonal labeling of the ligand with 123-I. With cold iodine and 64-Cu this complex shows excellent hypoxic selectivity in vitro and the results of in vivo studies of both the 123-I and 64-Cu labeled derivatives will be discussed together with their implications for the mechanism of selectivity for Cu(ATSM). Finally the availability of a wider range of 64-Cu and 99m-Tc radiolabelled bis(thiosemicarbazones) has enabled us to explore the impact of structure and the central metal on the mechanism of uptake of such complexes in cancer cells. These studies call into question several of the assumptions that have been made hitherto about the design strategies required to optimize the hypoxic selectivity of Cu(ATSM).
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