Abstract

The reaction of the hypothalamic neurosecretory system to prolonged starvation was examined in the fish,Misgurnus fossilis L. Two and four months of starvation resulted in storage of neurosecretory substance in the perikarya of the nucleus preopticus and in the preoptico-hypophysial tract. Further starvation, prolonged to five or seven months, caused degenerative changes in the nucleus preopticus. However, there were no drastic changes in the amount of stainable substance in the neurohypophysis. The examination of control animals revealed that the nucleus preopticus undergoes seasonal changes which differ from those brought about by starvation.

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