Abstract
Anti-Rh (D) antibody has been demonstrated to be nonhemolytic to Rh-positive red blood cells. However, fetal macrophages in vitro have been shown to bind Rh-positive red blood cells which are coated with this antibody. Promethazine hydrochloride inhibits the ability of fetal macrophages to bind Rh-positive red blood cells in vitro. These data suggest macrophage-mediated red blood cell destruction in erythroblastosis fetalis and offer one explanation for the success of promethazine hydrochloride in ameliorating the effects of this disease.
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