Abstract
Neptunium-237 is a hepatotoxin which dramatically increases lipid concentrations in female but not in male rats. The induction of fatty livers in female rats by 237 Np was ameliorated by adrenalectomy and hypophysectomy and by the administration of glucose, butylated hydroxytoluene or nicotinic acid. Ovariectomy, thyroidectomy, or the administration of adenine, ATP, methionine plus choline, or testosterone offered no protection. Castration or injection of estradiol did not increase the susceptibility of males to 237 Np-induced fatty liver. Serum activities of ICD and GPT were also elevated by 237 Np administration, with the increases being greater in the females than in the males. These rises in ICD and GPT activities were prevented by adrenalectomy and hypophysectomy, but not by the administration of ATP, BHT, glucose, or nicotinic acid.
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