Abstract
Butylated hydroxytoluene (BHT) fed to male mice for 4 wk gave significant protection against mortality caused by ethyl methanesulphonate (EMS), n-propyl or isopropyl methanesulphonate, ethylene dibromide, diethylnitrosamine and cyclophosphamide. It did not protect male mice against X-rays, methyl methanesulphonate (MMS), N-methyl- N′-nitro- N-nitrosoguanidine or dipropylnitrosamine, but female mice were protected from the lethal effects of MMS. Other agents, such as butylated hydroxyanisole, 1,2-dihydro-6-ethoxy-2,2,4-trimethyl quinoline and sodium phenobarbitone also gave protection against EMS toxicity. The protection, when it occurred, may have been due to the induction of drug-metabolizing enzymes.
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