MODIFICATION OF SUCROSE ADAPTATION IN THE RAT.

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Rats injected intraperitoneally (IP) with hypertonic sucrose solutions adapt to subsequent reexposures to the disaccharide by increasing 1) volume output of urine, 2) sucrose concentration of urine and 3) fraction of the injected load excreted within a 6-hour test period(1). Similar experiments employing intraarterial (IA) loading of the sugar demonstrated that the adaptation generated under these circumstances is qualitatively different from that induced by IP administration. Under conditions of IA infusion, re-exposure to sucrose causes a reduction in both total urine volume and the fraction of the load excreted in 6 hours, with no demonstrable difference in sucrose concentrations of urine(2). To determine whether the reductions in urine volume and sucrose excretion after a second IA infusion persist beyond the 6-hour period, experiments were conducted to examine the completeness of sucrose excretion over 24 hours. In addition a series of repeated IA loadings was performed to determine if the adaptive r...