Abstract
It is essential to design multifunctional contact lenses for selective recognition and utilization of the eye drop ofloxacin (OFL). Modified silicone hydrogel (MSL) contact lenses were firstly synthesized via ultraviolet curing by using (hydroxymethyl)methyl aminomethane, polydimethylsiloxane, methacryloxypropyl terminated polydimethylsiloxane, and N,N-dimethylacrylamide as monomers and N-vinyl-2-pyrrolidinone (NVP) as a modifier. The synthesized MSL contact lenses were characterized via Fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle and mechanical property tests. The results showed that compared with silicone hydrogel (SL) contact lenses, the MSL contact lenses had a more porous structure and good swelling and mechanical properties. The molecularly imprinted polymer/ofloxacin-modified silicone hydrogel (MIP/OFL-MSL) contact lenses were firstly synthesized via free radical polymerization, using ofloxacin (OFL) as the template molecule. Moreover, compared with chlorogenic acid and myricetin molecule, the MIP/OFL-MSL contact lenses exhibited an adsorption capacity for OFL that reached 2.86 mg/g. The antibacterial test showed that the MIP/OFL-MSL contact lenses displayed an inhibition ring size of 15.2 mm and 17.8 mm for Staphylococcus aureus and Escherichia coli, respectively.
Highlights
The incidence of visual problems and eye diseases is increasing with the rapid development and growing popularity of electronic products
Ofloxacin (OFL) is a third-generation quinolone, and OFL eye drops are largely used in the treatment of eyelid inflammation, conjunctivitis, and other eye diseases [1,2,3]
NVP was successfully introduced into the synthesis of Modified silicone hydrogel (MSL) contact lenses by ultraviolet curing, and the effects of NVP on the structure and properties were investigated
Summary
The incidence of visual problems and eye diseases is increasing with the rapid development and growing popularity of electronic products. The production of a drug’s macromolecular framework in the process of polymer synthesis has been proven to be capable of improving the drug loading of contact lenses and considerably accelerating the controlled drug release effect. Tieppo et al proved that ketotifen fumarate (Mw = 425), a small molecular weight therapeutic agent, can be successfully extended in vivo from molecularly imprinted contact lenses [25] Compared with those of topical drops and drug immersion lenses, the mean residence time and bioavailability of ketotifen fumarate are significantly increased. This finding indicates that molecular imprinting provides an exciting and reasonable engineering strategy for sustained release.
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