Abstract
The role of high-energy diets on adipocyte differentiation and gene expression as well as the contribution of high-fat intake to the onset of obesity is focussing much research. The aim of this work was to elucidate whether feeding on a high-energy yielding diet (cafeteria) induces a differential regulation on the expression of retinoic X receptor (RXRa). Female Wistar rats were assigned into four dietary groups receiving a high-fat (cafeteria) or control diet during 8 or 30 days. RXRa expression in white adipose tissue was assessed by a PCR protocol. The results show that body and abdominal fat weight was significantly increased in those groups fed (8 or 30 days) the high-fat diet as compared to those fed control diet. RXRa mRNA expression levels in white adipose tissue were significantly elevated after high-fat feeding as compared to appropriate dietary controls and the increase was markedly higher after 30 days feeding (+140%) than after only 8 day (+50%). These results support the involvement of this nuclear receptor, RXRa, in the growth of white adipose tissue after appropriate dietary stimulation (consumption of a high-fat diet). It would occur through changes in gene expression that may influence adipogenesis in a time-dependent fashion.
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