Modification of mesoporous silica nanoparticles with pH responsive polymer poly (2-vinylpyrrolidone) for the release of 5-Florouracil

Abstract

Mesoporous Silica Nanoparticles (MSN) as a platform for controlled drug delivery system (DDS) was studied. Highly interest has developed among researchers due to the physicochemical characteristic of MSN which has proven to be promising in drug delivery application. In this study, MSN was modified with polymer poly (2-vinylpyrrolidone) (PVP) by co-condensation method and it was characterized by X- Ray Diffraction (XRD), Transmission Electron Microscope (TEM) and Fourier Transform Infrared (FTIR). The result revealed that modification of MSN with PVP has improved drug loading and release of anticancer drug model 5-fluorouracil (5-FU) without major changes of MSN characteristic. As monitored by UV–Vis Spectrophotometer (UV–Vis) analysis, MSN-PVP enhanced the adsorption of 5-FU from 83% to 88%. Meanwhile, for release of 5-FU from MSN-PVP has increased from 66% for MSN to 81% by using MSN-PVP. Release profile pattern indicate the important of modification of MSN with polymer. Finally, through released profile of MSN-PVP, it has shown that the release of 5-FU was in gradually release condition as desired in DDS.