Abstract
ABSTRACTSuperparamagnetic Fe3O4 nanoparticles (MNPs) were functionalized by modified cellulose. The modified cellulose was synthesized through bromoacetylation of cellulose (BACell) followed by the substitution of sodium azide to form BACell-N3. The remaining methylene bromide groups on BACell-N3 was further reacted with the MNPs to form Fe3O4/Cell-N3. Then propargyl alcohol (PA) was immobilized on the azide-terminated Fe3O4 nanoparticles through copper (I)-catalyzed azide-alkyne cycloaddition (click reaction) to form Fe3O4/Cell/TAA nanoparticles. Doxorubicin (DOX) was loaded on prepared nanoparticles and release profiles of the DOX as a model drug from the Fe3O4/Cell/TAA nanoparticles and its loading capacity were determined by UV–Vis absorption at λmax 483 nm.
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