Abstract
Various factors are involved in the maturation and differentiation process of monocytes to macrophages and subsequent foam cell formation in atherosclerotic lesions. Macrophage colonystimulating factor, in particular, specifically promotes growth and differentiation of the monocyte-macrophage lineage, by activating various functions in mature macrophages and by influencing the atherosclerotic process. Vascular smooth muscle cells migrate from the media to the intima of the arterial wall, where they are transformed into macrophage-like foam cells that express two characteristic macrophage genes, scavenger receptor and macrophage colony-stimulating factor receptor genes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
