Abstract
The activity of drug-metabolizing enzymes in hepatic microsomes of rats with inflammatory lesions was determined. In the Donryu-rats carrying carrageenin-induced granuloma, the cytochrome P-450 and b5 levels and the activity of aniline hydroxylase in hepatic microsomes were depressed markedly at day 6 after s. c. injection of carrageenin when the granuloma formation and exudate accumulation occur rapidly. However, at day 15 after carrageenin injection when the granuloma is in regression, the activity of these enzymes was decreased slightly but without significant differences.
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