Abstract
This study aims to determine the composition of the ideal atherogenic diet to increase the risk of atherosclerosis in the animal model. The research was used 15 male mice, acclimatized for 1-2 weeks to get the susceptible amount of diet to be given. The animal objects are divided into 3 groups; normal diet group (control), 4 weeks atherogenic diet groups, and 8 weeks atherogenic diet groups. The modified atherogenic diet consists of common broiler food, wheat flour, pork oil, quail egg yolks, and water, given 2 times a day of 30 g of food. Water for animal objects is given ad libitum. After 4 weeks and 8 weeks total cholesterol, the formation of foam cells, and hepatocyte degeneration. The results show that the total blood cholesterol of animal models in the group of 8 weeks has the highest level (153, 66 ± 6, 51), compared to other groups (normal diet and 4 weeks). Animal models show that aortic cross-section formed foam cells in tunica intima and tunica media of endotel, also show the indication of hepar damage by hepatocyte degeneration.
Highlights
Atherosclerosis as a chronic inflammatory disease is a disease caused by abnormalities of lipid metabolism in the body [1]
Atherosclerosis is characterized by the accumulation of li-pids and formation of foam cells caused by modified lowdensity lipoprotein (LDL) uptake
The use of animal models in atherosclerosis research is important as an object to determine the pathogenesis, causes and pathways of the disease
Summary
Atherosclerosis as a chronic inflammatory disease is a disease caused by abnormalities of lipid metabolism in the body [1]. The use of animal models in atherosclerosis research is important as an object to determine the pathogenesis, causes and pathways of the disease. In this case the animals are often used are rodents [5], non-human primates, rabbits, dogs, pigs and other animals [6][7]. There are mice as animal models of atherosclerosis, they are not commonly used. We strive to formulate an atherogenic diet modification suitable for use in atherosclerosis research using mice as a more affordable, inexpensive, and susceptible animal
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