Modification in redox status of diabetes mellitus type 1 patients after insulin transition

Abstract

Aims To determine and compare an extensive array of biochemical redox indices before and after insulin type change in diabetes mellitus (DM) patients’ type 1. Methods Glutathione, malondialdehyde, peroxidation potential, superoxide dismutase, catalase, total hydroperoxide and advanced oxidation protein products in relation to blood glucose and glucose indicators control such as glycosylated haemoglobin and fructosamine were measured in 40 patients before and after 2 months since pork insulin was changed to human insulin in type 1 diabetic patients. These data was compared to sex and age-matched healthy control. Results After 2 months of changing, all indicator measured were favorably evolved and were significantly modified ( P < 0.05) except activity of erythrocyte enzymes superoxide dismutase and catalase. Adverse reactions (hypoglycaemic events) were observed in seven patients with 0.7% of incidence. It was related to concomitant use of captopril, clortalidone and nitropental for hypertension treatment. Simultaneous beneficial change in glucose, glucose control indices and redox markers were noted in 27 (68%) of total patients of study. Conclusion These results contribute to both evidences that transition process from animal to human insulin could be beneficial to DM type 1 patients and an integral overview about metabolic events involved could be valid for evaluate treatment effects. The results contribute to evidences that transition to human insulin can improve the antioxidant status of diabetic patients.