Modification in messenger RNA population synthesized in rabbit cerebral cortex in the recovery period following convulsions

Abstract

The labeling pattern of microsomal poly(A)-associated messenger RNA was studied in rabbit cerebral cortex during the postconvulsive period. Labeled uridine was injected into the brain 2 hr after a single electroconvulsive shock and the animals sacrificed 1 hr later. Poly(A) RNA was then extracted from cerebral cortex microsomes, and fractionated by gel electrophoresis. The results indicate that the messenger RNA population synthesized in the cortex in the postconvulsive recovery period is clearly different from that synthesized in the normal controls.